Graphical Assessment of Sliding P-values (GrASP)

Software version v.0.82 beta. March 2007

Overview

GrASP is a graphical tool to display and assess p-values from sliding window tests. It can present thousands of p-values from the sliding window tests as a simple graphic that uses varying levels of user-specified color to indicate the width of the sliding windows and the varying levels of significance. It therefore allows the user to identify regions/blocks of interest from these sliding windows, based jointly on the absolute p-value of the tests from these windows and the building of haplotypes of significance in the region. GrASP is executed as an Excel macro and is written in Excel's built-in version of Visual Basic for Applications.

GrASP has two main features:

(A) It extracts the information on the sliding window tests from user-provided input and creates a graphical overview to illustrate the size of each window and the p-value of the test for each window. This is referred to as the P-value Track. The P-value Track is always drawn by default.

(B) It illustrates the physical location of the SNPs and gene locations alongside the graphical overview of the sliding windows using either user provided input or by querying public databases (specifically Entrez). This is referred to as the Physical Track. This track is optional and is not drawn by default.

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